Growing potential for umbilical cord stem cells

Exciting development is to develop opportunities for umbilical cord stem cells, in accordance with article, published in November 2009, the opinion of an expert in biological therapy. This article discusses the development of carlecortemcel-l (brand of StemEx), strains of umbilical cord blood stem cells created by encouraging the proliferation of stem cells – without allowing to distinguish.

What does this mean and why is it important?

Although there is much evidence of the healing potential of stem cells extracted from the umbilical cord blood, it was claimed that a limited number of stem cells available from one unit of the banked is not sufficient for the treatment of patients other than children or adults is very small. Creating a method of multiplying these stem cells in their vital State of a pre-differentiated, researchers may potentially face this challenge and widen the application of multiple stem cell treatments.

The results of the phase I study carlecortemcel-l performed at the University of Texas m. d. Anderson Cancer Center reported in the article, suggest that the surcharges these stem cells enlarged umbilical cord is safe – and may be beneficial for adults and adolescents with leukemia and Lymphoma. The continuation phase II/III safety and efficacy studies named Are now registering youth and adults with a high risk of hematologic malignancies in clinical trials in the United States, Italy, Spain, Hungary and Israel. Gamida cell and Teva Pharmaceuticals, co-developers StemEx, predict the product officially reaching cabinets 2011.

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This entry was posted on 15 October 2009 at 12: 00 pm and is filed under the cord blood research. You can track any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback your own site.

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Reasons to Bank the umbilical cord blood-a public or private

There are many good reasons for the Cord Blood Bank. Not only is the collection of Cord Blood simple, painless and harmless for the mother and child, but Cord Blood stem cells are currently used to fight a wide range of diseases — more than 80 them! And every day, the test is carried out around the world to find more and better ways to use cord blood stem cells.

The question faced by the future parents who are considering Cord Blood banking, then, is whether to donate blood to the blood bank of the public (in this case, the blood would be most likely to go to the unrelated donor) or privately Bank blood for possible later use by the child or the family. Some organizations have spoken out against private banking, arguing that the benefits for children (autologiczne) are limited, and that the donation to the State banks should be encouraged instead.

Think we Bank cord blood of New England (NECBB), that families should be able to Bank Cord Blood public their child, if you want to do this for reasons of altruistic, but we believe that parents should have the option of saving their Cord Blood for children, where a threatening condition should occur in the future for their children or other family members.

Of life-threatening condition that requires the indication of the stem cells in your child or family, private banking provides immediate access to sources of stem cells with a higher likelihood of accurate or acceptable match for a child or family member, compared to stem cells from the donor is unrelated. For example, the probability that the stem cells will be the exact match is 1/1 for the child, from which collected stem cells, 1/2 for parents, children and 1/4 for the child's siblings.

In addition, in the course of the investigation and application of Cord Blood, stem cells in private bank the blood may become even more important.

Fortunately, we are not alone in this thinking. In a recent article, Journal of Hollands and McCauley in the journal stem cell reviews and reports, the authors State that the scientific evidence shows that is reasonable and rational choice, private banking, and that many critics of private cord blood banking, the overlooked potential benefit with the siblings or parents of children from whom detonating cord blood Transplants: blood collected from donors related are superior to transplants from unrelated donors, from the point of view of the results of clinical trials. Also important is the immediate availability of Cord Blood private storage benefits, as previously available, the lower the risk of death or advanced disease.

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This entry was posted on November 25, 2009 at 7: 14 pm and is filed under NECBB News. You can track any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback your own site.

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Umbilical Cord Blood MSC Cells Shown to Inhibit Breast Cancer Growth, What Else?

Umbilical cord mesenchymal stem cells (MSCs) have been shown to inhibit breast cancer cell growth but it is not known whether this effect is specific to only breast cancer cells. Investigators compared the effects of human Wharton’s jelly stem cell (hWJSC) extracts [conditioned medium (hWJSC-CM) and cell lysate (hWJSC-CL)] on breast adenocarcinoma, ovarian carcinoma and osteosarcoma cells. The cells were treated with either hWJSC-CM (50%) or hWJSC-CL (15µg/ml) for 48 hours – 72 hours and changes in cell morphology, proliferation, cycle, gene expression, migration and cell death studied. All three cancer cell lines showed cell shrinkage, blebbing and vacuolations with hWJSC-CL and hWJSC-CM compared to controls.  MTT and BrdU assays showed inhibition of cell growth by 2%-6% and 30%-60% while Transwell migration assay showed inhibition by 20%-26% and 31%-46% for hWJSC-CM and hWJSC-CL respectively for all three cancer cell lines.